Personally, I don’t think so. Like you point out if the Marxist Leninist instance has content you enjoy then why would you avoid it? - perhaps just don’t get into overtly political discussions / arguments.

You don’t have to be trans to visit or use a trans instance, non-anarchists can be on the anarchist instances, but do remember where you are and, most importantly, that you’re a guest/visitor and try to act accordingly. The same advice goes for .world

I’ve had no problems wherever I’ve gone - so far.